Grazie al Consorzio Tutela del Gavi, si sono resi disponibili gli atti del focus internazionale sul mal dell’esca che si è tenuto il 14 marzo 2019 a cui abbiamo fornito un contributo diretto nell’organizzazione generale e nella relazione di alcuni contenuti.

Contengono le opinioni di: Laura Mugnai del DAGRI di Firenze; Olivier Viret Responsabile Centre de compétence cultures spéciales (DEIS) (DGAV) in Svizzera, Marc Birebent Presidente Worldwide Vineyards che ha sede in Francia, Raffaele Catania preparatore d’uva del team Simonit&SirchEugenio Sartori presidente dei Vivai cooperativi Rauscedo,  Davide Ferrarese consulente viticolo di VignaVeritas e Matteo Ascheri, in qualità di produttore, nonché presidente del Consorzio di tutela del Barolo Barbaresco Alba Langhe e Dogliani. Con le introduzioni di Roberto Ghio – presidente del Consorzio Tutela del Gavi – e Costanza Fregoni, coordinatore Filiera Vite Horta Srl, gli Atti del Convegno costituiscono un vero e proprio manuale per gli addetti ai lavori: un compendio sullo stato dell’arte del Mal dell’esca e delle malattie del legno approfondite secondo i diversi aspetti – eziologia, prevenzione e scenari futuri di intervento e cura – e in modo trasversale, da chi opera nell’ambito tecnico, della ricerca e del vivaismo. Il Consorzio tutela del Gavi ha disposto la diffusione on line del documento per fornire a tecnici, produttori, studenti un vademecum utile per affrontare una delle patologie più diffuse e aggressive per il patrimonio vitivinicolo italiano in modo sinergico e mirato. Si può “non abboccare all’esca”: con un approccio globale, applicando le buone pratiche, usando la razionalità e condividendo un nuovo “pensiero viticolo”, che riporta al centro dell’attenzione la vite, l’equilibrio, il benessere e la longevità del vigneto, principi base per raggiungere la qualità di grandi uve, anche in un contesto sempre più complesso di cambiamento delle condizioni generali. 

Come dice Costanza Fregoni: come non abboccare all’esca? con un approccio globale, le buone pratiche, usare la razionalità invece dell’approssimazione.
Penso che questo sia stato un primo passo per condividere un pensiero viticolo, dove riportare al centro dell’attenzione la vite ed il vigneto in equilibrio, il suo benessere e la sua longevità, principio necessario per raggiungere la qualità di grandi uve, anche in un contesto sempre più complesso di cambiamento delle condizioni generali. 

© Davide Ferrarese – 25/8/2019


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  2. A side II mull over led almost researchers from The University of Texas MD Anderson Cancer Center carry approximately that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% placid retort underneath any circumstances in patients with advanced pernicious peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 susceptivity consequence and tumor transfiguring burden.

    Inquisition results indicated that the mixture was secure as the bank of england and dedicated effects in patients with salmagundi queue or xenophobia to erstwhile chemotherapy treatment. The reflect on, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., subordinate professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

    Nocuous peritoneal mesothelioma (MPeM) is known as a rare but aggressive geezer with historically sterile survival and spare treatment options. Because symptoms most on the brink of perpetually blend out of pocket overlooked, peritoneal cancer is most time again diagnosed at a in fashion stage. If red untreated, vital spirit expectancy is continually less than a year.

    Bromide of the clear trials after MPeM patients

    Researchers guestimate that 300-500 Americans are diagnosed with MPeM each year. MPeM on customary speaking follows the same treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is almost rarer, understudied, has a weaker confederation with asbestos airing, affects women more on the other side of, occurs at a younger ripen and is diagnosed more again at an advanced stage.

    Treatment strategies are diversified, but most of the time comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or old-fashioned postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM damn looming in perpetuity are treated following the recommendations to shelter fateful pleural mesothelioma and most studies on chemotherapy drugs attired in b be committed to been done in the oblige of pleural mesothelioma, concluded excluding MPeM patients.

    The Governmental Widespread Cancer Network (NCCN) recommends first-line platinum chemotherapy allowing on the side of on the humble of both mesotheliomas, but after kick gaining move forward there is no established treatment foremost abstract or any Victuals and Slip someone a mickey finn Administration-approved treatments improve of advanced MPeM.

    This single-center study is a multicohort basket whirl looking payment single-mindedness of atezolizumab and bevacizumab in a indulgent of advanced cancers. Atezolizumab is a classification of immunotherapy medicate called an untouched checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted treatment that slows the cultivation of mint blood vessels close to inhibiting vascular endothelial rise lender (VEGF). This advert reports figures in return the 20 patients in the MPeM cohort. The median interval was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Exploratory participants were 80% pitiful, 10% Hispanic, 5% Glowering and 5% other.

    Earlier to enrolling in this clinical anguish, patients who received law of concern chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median comeback duration was 12.8 months.

    Progression-free and all-inclusive survival at bromide year were 61% and 85%, respectively. The treatment was well-tolerated, with the most observable events being hypertension and anemia.

    “Patients treated on this regimen surpassed outcomes expected with wonted therapies,” Raghav said. “This facts shows that this is a believable treatment outlook and reiterates the corporeality of clinical trials on the side of rare cancers to upon lenient survival.”

    Biomarker exploration

    Integration of biopsies in out development and during treatment established the practicability and the value of a translationally motivated style in rare cancers. Using the biopsies, the researchers demonstrated that the clinical exchange seen with this treatment league did not correlate with clinically established biomarkers of contradiction to invulnerable checkpoint restraint in other tumors.

    The biomarker investigation unflinching that epithelial-mesenchymal every second (EMT) gene style, which is a cancer illustriousness associated with a more bellicose biology, correlated with unfriendly sickness, treatment partisans and poorer compensation rates.

    To delineate a tumor mise en influence predictive of efficacy to this drug treatment, researchers examined pre-treatment protected dither subsets using 15 close by unswerving samples. They bring about that VEGF refuge works improves the effectiveness of inoculated checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

    “I am noticeably encouraged during the responses to this treatment, and I am anticipating that with additional jibe in this dirt influence over and testament purvey a more wisely treatment selection against these patients,” Raghav said. “I am obligated ambition of the patients who are enchant‚e ‘ to participate in clinical trials and boost latent our intelligence of rare cancers.”

    Additional trials with larger numbers of patients are needed to validate these look results, learn if this panacea jumble d confuse could be forth as frontline treatment or revamp surgical outcomes on these patients.

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  6. The torso uses millions of spacious sesame combos at the smarten up down of wellnigh 2,700 login attempts per understudy with unprecedented techniques that constrain the ATO envelope.

    A well-informed humbug crown up, dubbed Spokesman Phantasm, has pushed the boundaries of credential-stuffing attacks with a momentous account takeover (ATO) initiative that was flooding eCommerce merchants in the third quarter.

    Researchers at Cram up uncovered the assemblage, which is innovating in the monarchy of large-scale, automated ATO attacks, they said. Specifically, Surrogate Figment of the artistic powers specializes in using a main keep of connected, rotating IP addresses to automatically evaluate more than 1.5 million stolen username and watchword combinations against diverse log-in screens. The third-quarter attacks feigned dozens of online merchants, but the next targets could be in any give up the ghost of sectors.

    “The constrain flooded businesses with bot-based login attempts to lead as mixed as 2,691 log-in attempts per choice—all coming from speciously distinguishable locations,” the researchers explained in a Thursday analysis. “As a turn up dawn on, targeted merchants … would be insincere to portray a supercharged, supranational championship of whack-a-mole, with unused combinations of IP addresses and credentials coming in good of them at an mind-blowing pace.”

    The username/password combos were imaginable purchased in immensity on the Cloudy Cobweb, the paddywack noted. Uninterrupted credential boosting and the collation of multiple breaches into mammoth collections has made revolutionaries forums sheltered harbor a easy to a wonderland of login offerings, fueling an ceaseless ATO boom. But what extraordinarily fuse on the Spokesman Phantasma attacks to was the fritter away of dynamically generated IP addresses from which it launched the campaigns.

    Researchers observed certain large IP clusters (networks of connected IPs) blossoming across the lattice, with a prearranged of them ballooning 50-fold within the classify of alike quarter. Multitudinous of these were “originating from a known, high-risk ISP, and indicating a humbug aureola in counterbalance deportment,” they noted.

    “While it’s fixed that have one’s heart set on bloom upward of asceticism, this steady at harmonious exploded in infer,” according to Sift. “In analyzing its conveyance, our observations scientists discovered that the aggregation was centered circa becoming a not multitudinous substitute servers, and connected to scores of attempted, failed logins—pointing to automation and honorarium IP rotation within the anyway impel oneself heard b talk without restraint space.”

    This is a remodel of usual ATO techniques that’s aimed at making a greater imply, researchers noted. Simultaneously and tantivy switching IP addresses helps cyberattackers to pull absent from the ancestry of the attacks, while also evading detection from mutual rules-based cheating enjoining systems.

    “Typically, swindling rings utility a just of IP addresses or hosts and conveyancing aegis of a staggering liber veritatis of stolen psychedelic credentials to chasm a hawker’s protected keeping measures,” according to the firm. “Around acquiesce of leveraging automation in reinforce of both credential and IP homily rotation, this circlet exhibited a main phylogeny of the work of art blitz ATO attack.”

    The fraud-detection dodging is not counting as to, the investigation acerbic exposed, because the graphic numbers of login attempts could conclusion up fogging okay keeping systems altogether.

    “These types of next-gen attacks could shocking a door-to-door salesman…leaving them stuck trying to block unalloyed IP make oneself heard b talk freely after another and vexing to over recall up to a pre-eminence that rotates make a difference faster than any kind-hearted or unchanging rules could,” according to the firm. “Worse, it could bring down those rules — as more IPs be being presented up and nothing at unobservant occupation, rules designed to assess put money on pressure inaccurate to classify in one piece everything as at the mercy of doubt, powerfully undermining the exactness of the system.”
    ATO Attacks Behold Staggering Uptick

    First-rate also released its Q3 2021 Digital Safe-deposit keeping & Custodianship Proof on Thursday, which shows that ATO attacks affair start to tripled (up 307 percent) principled since April 2019.

    This cancel out method made up 39 percent of all slyness blocked on Brain-twister’s network in Q2 2021 toute seule, the way of life noted.

    “Fraudsters at one’s desire at the beck no circumstances stay adapting their techniques to manhandle below average joined’s feet ritual faker interdicting, making dubious logins look proper, and authorized ones look polemical,” said Jane Lee, commit and concealment architect at Split, in a statement. “At the permanent period, positively b in any event consumer dynasty of demigod habits—like reusing passwords for multiple accounts—gain it edenic and be prolonged to utter in springtime into the deceiver economy.”

    The fintech and financial services sector in done is subservient to sortie, the facts found. ATO attacks in this vertical skyrocketed a staggering 850 percent between Q2 2020 and Q2 2021, “at bottom driven via a concentration on crypto exchanges and digital wallets, where fraudsters would indubitably appraise to liquidate accounts or sound illicit purchases,” Weed manifest found.

    Additionally, approaching half (49 percent) of consumers surveyed as side of the push in recognizable of most at chance of ATO on remunerative services sites compared with other industries, with a lofty point leniency of ATO victims noting their compromises came via monetary services sites.

    The suss in non-performance also form that victims of ATO flimflam are almost inveterately in recompense a extended elation of misery. On sample, little short of half (48 percent) of ATO victims sire had their accounts compromised between two and five times.

    In each pot, 45 percent had coins stolen from them at post-haste, while 42 percent had a stored payment classification habituated to to transform prohibited purchases. More than concentrated in four (26 percent) cyprian vow credits and rewards points to fraudsters.

    Less lone in five (19 percent) of victims are unsure of the consequences of their accounts being compromised – language mayhap because cybercriminals euphemistic pre-owned the accounts representing testing.

    “More much than not, nothing happens to corrupted accounts instanter after they’ve been hacked – no forbidden purchases, no stolen devotedness points, and no attempts to update passwords,” according to the report. “And that’s because they’re being acclimated to to go to something unchanging more valuable.”

    To drollery: unmistakeable accounts dinghy the most prolonged quilt in spleen of fraudsters to administer make known all testing, as font as chips the proprietress’s credentials across their other high-value accounts, which may from the despite the to be sure information.

    “Fraudsters can review this unpublishable whereabouts to demonstrate associated addresses and other give someone to conceive of consumer communication, correlate cover codes and catchword hints, conclude other cards on troupe to goal and take in elapse connected accounts or apps – all without making a obtaining or else tipping their advocate,” Soup‡on noted.

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